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The men were randomised to Weight Watchers weight loss programme plus placebo versus the same weight loss programme plus testosteroneand placebo. There were four treatment groups: weight loss only, Weight Watchers plus testosterone plus placebo, Weight Watchers plus testosterone plus placebo plus 1 tablet of DHEA plus DHEA, and Weight Watchers plus DHEA plus testosterone plus placebo. Treatment lasted four weeks, weight loss injections in stomach. For each individual in each group (male and female), the primary outcome was BMI measurements (in kg/m2) using the modified Eaton equation. A secondary outcome was change in the ratio of lean vs fat mass, weight loss affirmations. Results From 1611 men (mean age 24, weight loss pills no exercise.5 ± 0, weight loss pills no exercise.6 years, range 19–51 years), 1239 men were randomized to follow the Weight Watchers programme alone, 1233 men were randomized to the Weight Watchers plus testosterone and placebo groups, and 577 men were randomized to the Weight Watchers plus DHEA + DHEA groups, weight loss pills no exercise. Baseline characteristics are presented in table 1, weight loss injections in stomach. At the 12-week baseline evaluation (baseline versus two weeks posttreatment), mean absolute BMI was higher in the Weight Watchers plus testosterone plus placebo group (mean BMI 23.9 ± 0.6 kg/m2, 95% CI 20.0–25.6; number needed to treat at the end of the study, 23.0; P for trend = 0.06; ). On the basis of the mean change from baseline in BMI, mean BMI gain (at 12 weeks) in each weight loss group was −0, weight loss affirmations.2 (−3, weight loss affirmations.5 to 0, weight loss affirmations.6) kg, the DHEA + DHEA groups −1, weight loss affirmations.1 (−3, weight loss affirmations.1 to 2, weight loss affirmations.5) kg, and the Weight Watchers plus testosterone plus placebo groups −2, weight loss affirmations.2 (−4, weight loss affirmations.7 to 4, weight loss affirmations.0) kg (P for trend < 0, weight loss affirmations.01; ), weight loss affirmations. Weight loss on Weight Watchers plus testosterone plus placebo plus 1 tablet of testosterone Weight loss on Weight Watchers plus testosterone plus 1 tablet of testosterone was smaller in all groups (P < 0.005). From baseline to 12 weeks follow-up, each of the four treatment groups had a mean change in BMI in kg/m2 of −0.10 (−1.8 to −0.4) kg in men who received Weight Watchers plus testosterone plus placebo (P < 0.05), −1.6 (−6.1 to 3.6) kg in men who received Weight Watchers plus DHEA + DHEA (P < 0.05), and −2

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